Lead generation of 1,2-dithiolanes as exon 19 and exon 21 mutant EGFR tyrosine kinase inhibitors

Bioorg Med Chem Lett. 2019 Jun 15;29(12):1435-1439. doi: 10.1016/j.bmcl.2019.04.029. Epub 2019 Apr 20.
No abstract available

MeSH terms

  • Exons / genetics*
  • Humans
  • Mutation
  • Protein Kinase Inhibitors / pharmacology
  • Protein Kinase Inhibitors / therapeutic use*
  • Thioctic Acid / analogs & derivatives*
  • Thioctic Acid / metabolism

Substances

  • 1,2-dithiolane
  • Protein Kinase Inhibitors
  • Thioctic Acid